I should probably stay out of this discussion, but here goes anyway.
As all my friends will tell you, any time the discussion turns to .44 RemMag loads, I will eventually say something along the lines of, "In my opinion, the .44 Magnum is best with cast bullets."
In 20 years of reloading for .44 RemMag revolvers and rifles, I doubt if I've loaded over 100 rounds of jacketed bullets. I am a great believer in hard cast bullets, especially semi-wadcutter designs.
I'd start my load development using a 240-250 grain hard cast SWC and Unique. If that didn't work out, I'd try some 275-325 grain Long Wide Nose bullets from Cast Bullet Technology and try Unique, Win 296, and H-110.
If you can't kill a deer with a 240 gr. SWC, or a 300 grain LWN, you need to do some target practice.
Doc