The biggest problem with gun questions is that everyone who owns one thinks he's an expert. On the other hand ... I am one.
Since you ask the question, you apparently are not an expert on semi-auto handguns. For me, this tells me only one thing -- you should buy a revolver, for a lot of different reasons. They're cheaper, more reliable, easier maintenance, and can sit in a drawer for decades and still fire the first time, every time. Anyone who says this is true with slide-guns is an amateur.
At 3am, when you wake up facing some intruder with a knife or pistol, you aren't going to remember whether the safety is on ... or if there's one in the chute ... you'll be in a dead panic and lucky to grab your gun in time. And an improper, hurried grip almost guarantees you'll jam after the first shot and tear your hand up to boot. Especially if it's a Glock. You may only get one chance -- don't waste time on some frilled-up slide gun. Get something you just point & pull the trigger.
Yeah, I know -- the TV & movies turned slide guns into some sort of cultural icon, and even cops fell for it. The big capacity is nice ... though show me someone who's ever needed it in a firefight, even a cop. If you can't hit an intruder (or a mugger) with six shots, those extra rounds probably won't help you either. Better to spend a couple hundred less, buy a medium-priced revolver, and spend that money on PRACTICE ammo. Assuming your life is somewhat important to you.
Revolvers will swallow any brand or load of ammo and fire every time. Semi-autos sometimes are picky about what ammo you use, or how old or nasty it is ... might not even cycle properly with that ammo you stuck in there 3, 4, 5 years ago.
My wife and I have 35-40 guns, shoot thousands of rounds each year just here on the farm, and like our slide guns -- but we ONLY carry .357 revolvers, and that's what's on the nightstands, right next to the 12-gauge pump.
The best shooter I know swapped to a .380 to save carry weight, but swapped back to a .357 after finding a feral dog ripping up his chickens. He grabbed the .380 fast, fired, and the slide tore the web of his thumb and jammed. He threw it at the dog and grabbed a piece of 2x4 (with the hand that wasn't bleeding), but it could have been worse. He's back to the .357 and doesn't complain about the weight. And he shoots competition, is an ex-cop, and goes through probably 5,000 rounds a year.
If you want to throw lead at the range, buy a semi-auto. If you're serious about self-defense, do yourself a favor and get a .357. You can carry a hairy load and still shoot cheap .38 ammo for fun. For the money, a Ruger .357 is about as good as it gets, though Taurus is pretty impressive for the money, too.