Yes and no.
I am a long, long, time Redhawk owner.
Keep in mind - the Redhawks have been around since what - the late 1970's?? This means we got plenty of 40 year old 44mag Ruger stainless Redhawks kicking around that are probably not gonna handle too much more, Captain!
Back then - S&W did an ad campaign showing a Redhawk made into a sandwich - staying that thicker wasn't always better.
If you are gonna push a big bore pistol - a new new Redhawk is a great choice. But - keep in mind the gun is going to eventually pay the price. A steady diet of hot loads means one day the cylinder isn't going to move very fluid, or, one cylinder is going to shave lead. This gun will eiether become a safe queen, a practice gun, an expensive repair, or a gun you have to cut up with a torch.
I only used super hot loads in my 44Mag when I was shooting Pistol Silhouette on the Rams at 200 yards and for bear protection. I sold those 44's when I left Kodiak - and re-invested in the much more powerful 480 Ruger in the Stainless Redhawk. Upside to the 480 - you don't have to load it hot - because you don't wanna load it hot - because it is gonna hurt your hand too much!
Bottom line. In my experince - a box or two of hot loads a year isn't going to bother a Redhawk in 44Mag. If you find you really need more power than the 44mag - then you need to be looking at the 480, the 475, 454, 460 or 500. You need the right tool for the right job. The 480 in standard load is 290% more powerful than a 44mag. The other 4 are over the top more powerful than that. I do not own them because I can't hit nuttn' on the second shot - too big. With the 480 I can get all six into the target black at 50 yards rapid fire. (much better to hit with a less powerful gun - then to miss with the perfect gun)
I am on the road and don't have my reloading notes. My favorite all power load was with H110 powder - not only did you get power - you got more noise and tons of flash! We used to touch a few of these off at our indoor range and scare the be-jesus out of the other shooters for a laugh. Standing on the firing line, with the partitions between you and the other shooters - you could feel the whoosh of air go past your head when it went off - not much unlike the push of air when a subway train comes into station. Email me - I will send the load for this when I get home next weekend. I am in Spokane for the week.
Hope this helps.